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If you experience any unexpected symptoms whilst participating in a trial, you should: Contact your trial coordinator immediately, as trial participants must report adverse events through their study team Report suspected side effects via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk if appropriate Seek urgent medical attention if symptoms are severe Current Availability and Regulatory Status in the UK Neither cagrilintide nor retatrutide holds MHRA marketing authorisation in the UK

36,37 It is thought to negatively impact reproductive function by increasing inflammation, insulin resistance, and oxidative stress

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Many would develop scurvy, a life-threatening vitamin C deficiency